Correction of Antidiuresis by Demeclocycline

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Abstract
ALL the signs and symptoms of the syndrome of inappropriate secretion of antidiuretic hormone result from excessive retention of water. Accordingly, adequate restriction of water and fluid intake prevents the hyponatremia and the associated clinical manifestations. Since the original description of the syndrome, severe fluid deprivation has been the only therapeutic approach in the chronic form.1 Unfortunately, this therapy causes much discomfort to the patient, and, when not followed, results in repeated and sometimes life-threatening episodes of water intoxication. Recently, lithium carbonate has been successfully used in a patient with the syndrome,2 but this drug is frequently associated with inconvenient . . .