FATE OF OESTRIOL-3-SULPHATE AND OESTRIOL-16-GLUCOSIDURONATE IN THE INTACT FOETO-PLACENTAL UNIT AT MIDPREGNANCY

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Abstract
In two cases of therapeutic abortion by laparotomy, tracer amounts of 3H-labelled oestriol-3-sulphate (OE3-3S) and 14C-labelled oestriol-16-glucosiduronate (OE3-16GI) were injected into the umbilical vein 15 minutes prior to the interruption of gestation and the radioactive material recovered from the maternal urine, placenta, various foetal tissues and urine was analysed. Some four times more 3H- than 14C-labelled material was excreted in the urine of the mothers. Approximately 90% of both isotopes was identified as OE3-16GI. From the placentas more than twice as much 14C- as 3H-labelled meterial was recovered. All the 14C-labelled material was present in the form of glucosiduronate. Approximately 40% of the 3H-labelled material was identified as unconjugated oestriol (OE3), some 2% was present in the form of unidentified unconjugated material, and the rest was OE3-3S.3-3S. All the 3H-labelled material present in the foetal organism was identified as OE3-3S, indicating lack of metabolism of this conjugate by the foetus. On the other hand, the 14C-labelled OE3-16GI was metabolised by the foetus. A small part of it was converted into OE3-3S, which was present only in the liver. In addition, all foetal tissues contained considerable quantities of 14C-labelled oestriol-3-sulphate,16-glucosiduronate (OE3-3S,16GI) accompanied by smaller amounts of a 14C-labelled glucosiduronate of OE3, which was considerably more polar than OE3-16GI. The foetal urine contained only 14C-labelled glucosiduronates of OE3.

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