Two types of calcium channels sensitive to ω-agatoxin-TK in cultured rat hippocampal neurones

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Abstract
We characterized the electrophysiological properties of calcium channels in cultured rat hippocampal neurones using ω-agatoxin-TK (ω-Aga-TK) and compared them with those of the P-type channel and the BI (α1A) channel which resembles the Q-type channel. Two types of ω-Aga-TK-sensitive calcium channels were detected in hippocampal neurones. The first type showed slow inactivation, high sensitivity to ω-Aga-TK and low reversibility from ω-Aga-TK-induced block, resembling the P-type channel. The second type showed fast inactivation, low sensitivity to ω-Aga-TK and high reversibility from ω-Aga-TK-induced block, resembling the Q-type channel. The glutamatergic synaptic transmission showed low sensitivity to ω-Aga-TK and high reversibility from ω-Aga-TK-induced block. These results suggest that the second type of calcium channel (Q-type-like) plays a prominent role in the hippocampal synaptic transmission.

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