Human parathyroid hormone gene (PTH) is on short arm of chromosome 11
- 1 September 1983
- journal article
- research article
- Published by Springer Nature in Somatic Cell and Molecular Genetics
- Vol. 9 (5) , 609-616
- https://doi.org/10.1007/bf01574261
Abstract
The human gene for parathyroid hormone (PTH) was chromosomally mapped using human-rodent hybrids and Southern filter hybridization of cell hybrid DNA. A recombinant DNA probe containing human PTHcDNA insert (pPTHm122) hybridized to a 3.7-kb fragment in human DNA cleaved with the restriction enzyme EcoRI. By correlating the presence of this fragment in somatic cell hybrid DNA with the human chromosomal content of the hybrid cells, the PTHgene was mapped to the short arm of the chromosome 11.Keywords
This publication has 32 references indexed in Scilit:
- Clustering of Leukocyte and Fibroblast Interferon Genes of Human Chromosome 9Science, 1982
- Mapping the Human Genome, Cloned Genes, DNA Polymorphisms, and Inherited DiseasePublished by Springer Nature ,1982
- Nucleotide sequence of cloned cDNAs encoding human preproparathyroid hormone.Proceedings of the National Academy of Sciences, 1981
- Leukocyte and fibroblast interferon genes are located on human chromosome 9.Proceedings of the National Academy of Sciences, 1981
- Cloning and nucleotide sequence of DNA coding for bovine preproparathyroid hormone.Proceedings of the National Academy of Sciences, 1979
- Assignment of the β-glucuronidase structural gene to the pter→q22 region of chromosome 7 in manCytogenetic and Genome Research, 1978
- Correction of human mucolipidosis II enzyme abnormalities in somatic cell hybridsNature, 1977
- Assignment of hexosaminidase-B to chromosome 5, its segregation after diphtheria toxin selection, and the linkage of hexosaminidase-A, mannose phosphate isomerase, and pyruvate kinase (M2)Cytogenetic and Genome Research, 1976
- Genetics of human-mouse somatic cell hybrids: Linkage of human genes for isocitrate dehydrogenase and malate dehydrogenaseBiochemical Genetics, 1972
- A RAPID BANDING TECHNIQUE FOR HUMAN CHROMOSOMESThe Lancet, 1971