Single dose antibiotic prophylaxis of surgical wound sepsis: which route of administration is best? A controlled clinical trial of intra-incisional against intravenous cephaloridine
- 1 March 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 7 (3) , 223-227
- https://doi.org/10.1093/jac/7.3.223
Abstract
Four hundred and five consecutive patients undergoing emergency or elective abdominal operations under the care of one surgeon were randomly allocated to receive prophylaxis against wound sepsis by means of a single dose of 1 g cephaloridine given either intravenously at the start of, or into the incision at the end of, operations. Ten patients died within 2 weeks without wound sepsis and in the remaining 395 patients there were no significant differences between the two groups in the rates of major (3 5% and 2 1%) or minor (12 4% and l5 5%) wound sepsis.Keywords
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