Lack of association of HLA class I genes and TNF α‐308 polymorphism in toluene diisocyanate‐induced asthma

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Abstract
Background: Toluene diisocyanate (TDI)‐induced asthma is a common cause of occupational asthma and it affects 5–15% of the exposed population suggesting an underlying genetic susceptibility. Methods: To investigate the role of genetic factors in the development of TDI‐induced asthma, we analyzed the distribution of human leukocyte antigen (HLA) class I genes and of tumor necrosis factor (TNF)‐α A‐308G polymorphism in 142 patients with TDI‐induced asthma and in 50 asymptomatic exposed subjects. Results: Neither the distribution of HLA class I antigens nor the distribution of TNF‐α A‐308G polymorphism was different between patients with TDI‐induced asthma and asymptomatic exposed subjects. Conclusions: These results suggest that HLA class I antigens and TNF‐α A‐308G are not associated with susceptibility or resistance to the development of TDI‐induced asthma.