Real-Time Gas Chromatography/High Resolution Mass Spectrometry and its Application to the Analysis of Physiological Fluids
- 1 November 1974
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Chromatographic Science
- Vol. 12 (11) , 647-655
- https://doi.org/10.1093/chromsci/12.11.647
Abstract
Accurate mass measurement of all peaks in a mass spectrum is a significant advantage in aiding rapid identification of unknown components in gas chromatographic effluents. These data provide elemental compositions which speed the interpretation of the mass spectrum, especially when the mass spectra of such unknowns are not contained in current files of low resolution mass spectral fragmentation patterns. The development of real-time high resolution mass spectrometry at high sensitivity has provided the capability for determining high resolution mass chromatograms from continuous cycle operation. Previously reported mass measurement accuracy, dynamic range, and scan cycle is discussed with reference to the GC/HRMS mode, and examples presented from the analysis of urinary organic acids.Keywords
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