Asymmetric Synthesis XIII: The Stereocontrolled Synthesis of (R)—α—Amino Acids via a Double Chiral Induction
- 1 April 1991
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 21 (8) , 1087-1090
- https://doi.org/10.1080/00397919108019799
Abstract
The stereocontrolled synthesis of (R)—α—amino acids via a double chiral induction in alkylation of the ketimine derived from (+)—camphor and (+)—menthyl glycinate which is a chiral match pair has been studied. (R)—α—amino acids wih high optical purity 80–90% are obtained after hydrolysis of the alkylated products. We find that the chiral match which is the symergistic effect in a double chiral induction is very important to abtain the higher diastereoselectivity for the stereocontrolled synthesis.Keywords
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