Dendritic regrowth of retinal ganglion cells in adult rats

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Abstract
IN adult rat retinal ganglion cells, we investigated how their dendrites are maintained during axonal regeneration induced by a peripheral nerve (PN) graft. Intracellular Lucifer Yellow injection revealed that rapid dendritic retraction occurred immediately after axotomy and grafting. However, dendrites that probably sprouted after axotomy were often found in the regenerating ganglion cells, and their dendritic field tended to recover in area by 3 months after grafting. Although such dendrites were also found in an axotomized cell receiving no PN graft, they are much more frequently observed in the regenerating cells. Therefore, a PN graft can facilitate the rat ganglion cells to regrow their dendrites.

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