PROTECTIVE EFFECT OF HYDROXYZINE AND PHENYLPROPANOLAMINE IN THE CHALLENGED ALLERGIC NOSE
- 1 January 1981
- journal article
- research article
- Vol. 47 (5) , 316-319
Abstract
Allergic rhinitis patients were challenged with intranasal allergen aerosols after pretreatment with hydroxyzine and phenylpropanolamine, singly and in combination. Hydroxyzine protected against itching, sneezing and hypersecretion but aggravated obstruction. Phenylpropanolamine had a subtle but measurable anti-congestive effect. This model quantitates and confirms the complementary effects of combined antihistamine-decongestant therapy.This publication has 3 references indexed in Scilit:
- Inhibition of the immediate allergic reaction in the nose by the beta-2 adrenostimulant fenoterolJournal of Allergy and Clinical Immunology, 1980
- Effects of Topical Use of β-Adrenoceptor Stimulants on Nasal Mucosa. Rhinomanometric Evaluations in Experiments with Terbutaline and KWD 2131: II. Nasal Provocation Tests with Hay Fever Patients in Asymptomatic PeriodActa Oto-Laryngologica, 1980
- Suppression of seasonal allergic rhinitis symptoms with daily hydroxyzineJournal of Allergy and Clinical Immunology, 1979