Herpes Simplex Virus Nuclear Nonvirion Antigens Detected by Anticomplement Immunofluorescence
- 1 November 1976
- journal article
- research article
- Published by SAGE Publications in Tumori Journal
- Vol. 62 (6) , 609-614
- https://doi.org/10.1177/030089167606200604
Abstract
The finding of a nuclear antigen by anticomplement immunofluorescence in cells treated with cytosine-arabinoside after infection of Herpes Simplex Virus (HSV), opens a new approach to the problem of the role of this virus in certain human cancers. Complement-fixing tests of HSV markers with cancer and control human sera as well as with hyperimmune guinea pig antisera are discussed, suggesting another parameter for studies of squamous cell carcinomas. The finding of HSV antigens in selected tumors as the expression of repressed viral genome proves a continuing release of virus specific message and supports the important role of the virus in the development of the tumor.This publication has 7 references indexed in Scilit:
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