Diterpenoids from the Roots of Salvia hypargeia

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Abstract
From the root extracts of Salvia hypargeia, in addition to the known diterpenoids cryptanol and horminone, six new abietane diterpenoids [6-beta,12-dihydroxyabieta-8,11,13-triene-1,7-dione, 12,15-dihydroxyabieta-8,11,13-triene-7-one, 12-hydroxyabieta-8,11,13-triene-6,7-dione, 12-hydroxyabieta-6,8,11,13-tetraen-3-one, 6-beta,14-dihydroxyabieta-8,11,13-trien-1-one, and 5,12-dihydroxyabieta-6,8,12-triene-11,14-dione] were isolated. The structures of the new and the known compounds were established by spectral data. The new compounds, hypargenins A, B, C, D, and F, showed antibacterial activity, while hypargenin F was also active gainst Mycobacterium tuberculosis. Hypargenin E did not exhibit antibacterial activity.