Neuropeptide Y Lowers Blood Glucose in Anaesthetized Rats via a Y5 Receptor Subtype

Open Access

1 June 1998

journal article
other
Published by The Endocrine Society in Endocrinology

Vol. 139 (6) , 3018-3021
https://doi.org/10.1210/en.139.6.3018

Abstract

We have investigated the receptor subtype mediating effects of neuropeptide Y (NPY) on blood glucose concentrations. In anaesthetized rats a 120 min i.v. infusion of 2 μg/kg/min NPY lowered blood glucose by 26 mg/dl. This was mimicked by the same dose of peptide YY (PYY), NPY_2-36, PYY_3-36 and[ Leu³¹,Pro³⁴] NPY but not by NPY_13-36, PYY_13-36 or rat or human pancreatic polypeptide. The effects of NPY and[ Leu³¹,Pro³⁴]NPY were not inhibited by 10μ g/kg/min BIBP 3226. Neither treatment significantly altered plasma insulin concentrations. We conclude that NPY lowers blood glucose concentrations via a Y₅ receptor subtype, i.e. a subtype which has also been implicated in stimulation of food intake.

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