Dr. Moynahan reported recently the successful treatment of acrodermatitis with zinc sulfate. He informed us that nine of his patients have continued in remission with this treatment and that approximately 20 patients in Scandinavia are responding to this treatment. Since the use of diiodohydroxyquin is sometimes complicated by optic atrophy2 and since zinc treatment has not been reported in this country, we felt it important to describe the successful use of zinc sulfate in two patients and to urge physicians in the United States to try this treatment. CASE REPORTS Case 1 C.R. is an 8-year-old white girl diagnosed at 1 month of age as having acrodermatitis and subsequently studied for fatty acid metabolism3 and tryptophan metabolism.4