NI3S2-INDUCED LEIOMYOSARCOMAS IN RABBIT SKELETAL-MUSCLE - ANALYSIS OF THE TUMORAL MYOSIN AND ITS SIGNIFICANCE IN THE RETRODIFFERENTIATION CONCEPT
- 1 January 1981
- journal article
- research article
- Vol. 2 (1-2) , 101-108
Abstract
Leiomyosarcomas were induced in rabbit skeletal muscle by Ni3S2 implantation. Tumor myosin was isolated and compared with normal adult skeletal muscle myosin and cow uterine smooth muscle myosin. This leiomyosarcoma myosin precipitates as long fusiform filaments and possesses 2 light-chains of 25,000 and 18,000 daltons as does the onco-fetal type. Tumoral stem myoblasts apparently originate from retrodifferentiated muscle cells.This publication has 10 references indexed in Scilit:
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