Radiosensitivity of Continuous Cultures: II. Continuous γ-Ray Exposure

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Abstract
Continuous cultures of diploid yeast [model system] were continuously exposed to 60Co .gamma.-rays. Under continuous irradiation, a steady state was maintained even if the dose rate was sufficiently low. Critical dose rate levels depend on the chemostat turnover, i.e., the dilution rate. With higher dilution rates only lower dose rates can be tolerated. In any case, the tolerable dose rates were less than anticipated on the basis of assuming complete recovery from sublethal damage. Under conditions of substrate limitation recovery may be reduced due to the shortage of essential nutrients. [Long term exposure of cell populations or organized tissue to ionizing radiation at comparatively low dose rates may serve as an important tool for the study of systematic factors and recovery ability of the single cell and the population as a whole.].

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