Reduced Citrovorum Factor Rescue for High-Dose Methotrexate Therapy in Childhood Malignancies
- 1 January 1985
- journal article
- research article
- Published by Mary Ann Liebert Inc in Cancer Drug Delivery
- Vol. 2 (1) , 77-86
- https://doi.org/10.1089/cdd.1985.2.77
Abstract
Clinical toxicities and pharmacokinetics of methotrexate (MTX), associated with reduced citrovorum factor (CF) neutralization, were studied on 279 infusions in 25 children with various malignancies. MTX, at 1000-8400 mg/m2, was infused during 6-24 h with multiple schedules of reduced CF rescue. Plasma MTX levels ranged from 7.0 .times. 10-5 to 7.0 .times. 10-4 M during MTX infusion. The levels declined rapidly with a 2-phase elimination pattern (t1/2 half life = 1.2-2.5 h, t1/2 = 18-32 h). The folate level in the plasma ranged from 5 .times. 10-7 M to 1.4 .times. 10-6 M when CF was administered every 6 h or every 3 h, respectively. Limited bone marrow suppression was seen in only 7% of infusions, with moderate elevation of GOT [aspartate transaminase] and GPT [alanine transaminase] in 20% of infusions and stomatitis in only 2.6% of infusions, despite reduction in the total dose of CF from 225 mg-105 mg and despite delaying CF initiation from 9 h-36 h after the start of MTX infusion.This publication has 6 references indexed in Scilit:
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