Histological Patterns of Muscle in Infants with Developmental Brain Abnormalities

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Abstract
The histology of muscle obtained from 23 hypotonic infants without neuromuscular disease is presented. Long-term follow-up neurological examinations were carried out to determine the site of the lesion. Cases (18) have strong evidence of cerebral dysfunction, 12 of whom have histological abnormalities of fiber-type distribution and diameter. Of the remaining 5 patients without obvious cerebral abnormality, 4 also had histological changes, but individual circumstances partially explain the cause of the abnormal histological patterns in these 4. No single histological abnormality could be identified, but the histological abnormalities of muscle in hypotonic infants without clinical or microscopic evidence of neuromuscular disease may be useful in predicting a cerebral cause for the hypotonia.