Effect of Vitamin E and Beta Carotene on the Incidence of Primary Nonfatal Myocardial Infarction and Fatal Coronary Heart Disease
Open Access
- 23 March 1998
- journal article
- clinical trial
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 158 (6) , 668-675
- https://doi.org/10.1001/archinte.158.6.668
Abstract
THE INVOLVEMENT of oxidized low-density lipoprotein in the pathogenesis of atherosclerosis has raised interest in antioxidants as possible preventive agents of cardiovascular disease.1,2 Despite strong experimental evidence, the preventive effect of antioxidant supplementation on cardiovascular events in humans is unproven. In observational studies, use of vitamin E (alpha tocopherol) supplements has been associated with decreased risk for subsequent coronary events.3,4 Large-scale randomized trials with beta carotene supplementation have shown either no reduction in cardiovascular diseases5 or even an increase in cardiovascular mortality.6,7 In a placebo-controlled trial, vitamin E treatment significantly reduced the risk of nonfatal myocardial infarction in patients with coronary disease.8Keywords
This publication has 1 reference indexed in Scilit:
- The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male SmokersNew England Journal of Medicine, 1994