Transmucosal fluid movement and intestinal drug absorption in alloxan diabetic rats.

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Abstract
The effects of alloxan-induced diabetes on the relation between transmucosal fluid movement and its effect on sulfanilamide absorption were studied with the in situ recirculating perfusion method using the small intestine of rats with perfusion solutions having 3 different tonicities which were adjusted to hypertonic (1.2%), isotonic (0.9%) and hypotonic (0.6%) solution with NaCl, respectively. Sulfanilamide absorption in both control and diabetic rats was increased with increase in the apparent transmucosal fluid movement. The regression lines obtained from both of them were almost overlapped in a wide range of drug absorption on the horizontal axis and fluid movement on the vertical axis. The transmucosal fluid movement using the entire small intestine in diabetic rats were always significantly greater than in control animals. On both a wet- and dry-weight basis, the fluid movement was also significantly greater with the diabetics. The total drug absorption was significantly increased in the diabetics than in the controls. The drug absorption in the diabetics was also significantly increased than in the controls when compared on a dry-weight basis. The increased drug absorption in the diabetics might be based on the increase of fluid inflow rather than increased transport activity per unit weight of the intestine. The effect of transmucosal fluid movement on drug absorption may be the same characteristic in nature indifferent to the induced mechanisms which were due to artificial and natural devices.

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