INHIBITION OF THE OXYTOCIC ACTION OF PROSTAGLANDIN F2α ON PREGNANT RABBIT UTERUS BY INTRA-AORTIC INFUSION OF THEOPHYLLINE IN VIVO

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Abstract
A preparation has been described previously for the investigation of the action of various agents on the myometrium of the pregnant rabbit. This technique involves the insertion of specially prepared catheters into the femoral artery and vein under sodium pentobarbitone (Nembutal) anaesthesia. The catheters are passed cranially until the tips lie well above the level of origin of the ovarian arteries and veins. At the same time a pressure-sensitive radiotransducer is inserted into the uterus to record intrauterine pressure changes (Smith, Abel & Nathanielsz, 1973). The experiments reported here were performed on animals catheterized at day 21 of pregnancy and infused with 1 μg prostaglandin F2α (PGF2α through the aortic catheter for 16 h after recovery from anaesthesia. The PGF2α infusion was then stopped and the catheters were maintained patent with heparinized saline between experiments. This procedure resulted in the gradual evolution of spontaneous myometrial activity and

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