TRIAMCINOLONE (ARISTOCORT), NEW CORTICOSTEROID HORMONE

3 May 1958

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 167 (1) , 58-59
https://doi.org/10.1001/jama.1958.72990180001015

Abstract

For the 10 months prior to the time of writing we have been observing the effects of a new anti-inflammatory steroid hormone in allergic conditions. Its high potency and the fact that we noted other actions not customarily encountered with the other anti-inflammatory hormones prompt us to report our findings. This drug, triamcinolone ( 9α-fluoro-16α-hydroxy-Δ¹-hydrocortisone; Aristocort) was synthesized by Bernstein.¹The structural formula is as follows: The major features of the drug, as determined at Lederle Laboratories,²are the following: Its glucocorticoid activity is 3 to 12 times that of prednisolone in fasting adrenalectomized rats. Its anti-inflammatory activity, as measured by granuloma formation around asbestos pellets inserted in the backs of rats, is about equal to that of prednisolone and 10 times that of hydrocortisone. The most intriguing action of this drug is the marked diuresis and sodium removal obtained in adrenalectomized rats loaded with salt, as

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