Dextromethorphan Protects Retina Against Ischemic Injury In Vivo
- 1 March 1989
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Ophthalmology (1950)
- Vol. 107 (3) , 409-411
- https://doi.org/10.1001/archopht.1989.01070010419037
Abstract
• Retinal ischemia was induced in rabbits by increasing intraocular pressure above systolic blood pressure for 60 or 75 minutes, and retinal function was monitored by electroretinography. Pretreatment with intravenous dextromethorphan, a nonprescription antitussive and selective antagonist of N-methyl-d-aspartate receptors, enhanced greatly the post-ischemic recovery of b-wave amplitude. Dextromethorphan may prove to be useful clinically in the management of retinal ischemic disease.This publication has 9 references indexed in Scilit:
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