Evaluating drug treatments for Parkinson's disease: how good are the trials?

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Abstract
Identifying trials and extracting data To identify publications from 1966 to the end of 2001 we searched the Cochrane Library, NHS Centre for Reviews and Dissemination, and Health Technology Assessment databases for systematic reviews and Medline, Embase, PubMed, and the Web of Science for primary research. We hand searched major journals in the field, including Movement Disorders, Parkinsonism and Related Disorders, Neurology, and Journal of Neurology, Neurosurgery and Psychiatry. We contacted experts in the field in attempt to identify studies not found through electronic and hand searching, and scanned reference lists of retrieved papers and websites relating to Parkinson's disease. No restriction on study design was made other than randomisation. Unpublished and non-randomised studies were not included.