In vitroactivity of voriconazole against selected fungi
Open Access
- 1 January 1998
- journal article
- Published by Oxford University Press (OUP) in Medical Mycology
- Vol. 36 (4) , 239-242
- https://doi.org/10.1080/02681219880000361
Abstract
Fifty-nine isolates consisting of 14 genera and 33 species of ascomycetes, basidiomycetes, and zygomycetes were tested against amphotericin B, fluconazole, itraconazole and voriconazole using an in vitro modified macrobroth dilution procedure based upon the NCCLS M27-A standard method for yeasts. The triazoles voriconazole and itraconazole had similar MIC values, except for Acremonium alabamensis, A. strictum, Fusarium oxysporum, F. solani and Wangiella dermatitidis, whichhad substantially lower voriconazole MIC values. Voriconazole MIC values were lower than those for itraconazole for the 17 species of Trichosporon tested. Fluconazole had high MIC values, often greater than 128 µg ml-1.Keywords
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