Amberlyst-A21 as a New and Efficient Surface Catalyst for the Conjugate Addition of Nitroalkanes to Methyl Acrylate: An Improved Synthesis of Methyl 4-Nitro- and 4-Oxo-alkanoates
- 1 January 1987
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1987 (08) , 711-713
- https://doi.org/10.1055/s-1987-28054
Abstract
Utilization of Amberlyst-A21 without solvent in the conjugate addition of nitroalkenes to methyl acrylate, affords 4-nitroalkanoic methyl esters in good yields. Successive Nef reaction, using potassium permanganate, provides functionalized 4-oxoalkanoic methyl esters.Keywords
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