Limited diversity of HLA‐DRB1*02 alleles and DRB1–DRB5 haplotype associations in four United States population groups
- 1 March 2003
- journal article
- research article
- Published by Wiley in Tissue Antigens
- Vol. 61 (3) , 249-252
- https://doi.org/10.1034/j.1399-0039.2003.00018.x
Abstract
At least 60 DRB1*02 positive individuals from each of four US population groups found within a hematopoietic stem cell volunteer donor registry – Caucasoids, African Americans, Asians/Pacific Islanders, and Hispanics – were randomly selected from a database of 82,979 individuals. DRB1*02 alleles were identified by DNA sequencing. A total of five of 23 known DRB1*02 alleles were detected. DRB1*15011 was the predominant DRB1*02 allele in Caucasoids and Hispanics. The most common DRB1*02 allele observed in African Americans was DRB1*1503, and DRB1*15021 in Asians/Pacific Islanders. Caucasoids were found to be the least diversified; only DRB1*15011 and DRB1*16011 were observed. A subset of individuals was also typed for DRB5 alleles by DNA sequencing. DRB5*01011, DRB5*0102, DRB5*0103, DRB5*0108N and DRB5*0202 were detected and nine DRB1‐DRB5 haplotypes defined.Keywords
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