Residue of Dietary Tylosin in Blood, Muscle and Liver of Growing Chicks

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Abstract
Three experiments with 317 male and 40 female meat-type one-day old chicks in total were carried out to determine the residue of tylosin in the blood, breast muscle and liver of the chicks fed the diets containing various levels of tylosin for various weeks and of the chicks after the withdrawal of dietary tylosin. Five chicks at a time were sacrificed to determine the residue individually by microbioassay with Sarcina lutea ATCC 4341. No residue at all was detected after 8 weeks of tylosin feeding at dietary level less than 1, 000ppm, suggesting that the edible parts was free from tylosin residue on therapeutic use of this antibiotic. Even after feeding extremely high level of dietary tylosin at 8, 000ppm, no tylosin residue was detected in the blood at the first day, and in the muscle at the second day, after the withdrawal of dietary tylosin. The residue of tylosin in the liver disappeared exponentially within 5 days after the withdrawal. The relationship between days after the withdrawal (T days) and tylosin residue in the liver (y ppm) can be described by the following Equation 1, log y=0.6658-0.5013 T……(1) From this equation, biological half life of tylosin was estimated to be 0.6 days with 95% confidence interval between 0.4 and 0.9 days.

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