MANAGEMENT OF NON–HODGKIN'S LYMPHOMA *

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Abstract
Non‐Hodgkin's lymphoma differs from Hodgkin's disease in the frequency of extranodal and bone marrow involvement and in the unpredictability of spread. These features make staging less accurate and modify the approach to therapy. In clinically localized disease, radiotherapy may be effective treatment. However, many cases are disseminated at the time of diagnosis and require chemotherapy. The recent Introduction of combination chemotherapy has been associated with a high initial remission rate and, apparently, with a better prognosis.