HIGH RENIN-ACTIVITY ACCOMPANYING ANGIOTENSIN-II INHIBITION IN RATS WITH ISCHEMIC RENAL-FAILURE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 12  (2) , 124-128
Abstract
Acute renal failure was produced in rats by right nephrectomy and total occlusion of the left renal artery for 70 min. Angiotensin II competitive inhibitor, P113 (1-sar-8-ala-angiotensin II), was administered intravascularly for 100 min, starting 15 min before the clamping of the renal artery. A marked rise in plasma renin activity was observed 15 min after declamping and was significantly higher in the P113-treated rats than in saline-treated animals. The rise in blood urea and serum creatinine levels, 24 h after the experiment, was similar in the 2 groups, indicating that P113 does not prevent the development of acute renal failure in this experimental model. The marked rise in plasma renin activity may be due to interruption of the normal feedback mechanisms which suppress renin release, as a result of occupation of the angiotensin II receptor sites by P113.

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