Screening for alkaloids in toxicology by using thin-layer chromatography: a rapid system simulating paper chromatography

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Abstract
Although numerous thin-layer chromatographic systems for the separation of alkaloids have been reported, none of them compares in abundance of recorded RF values with the citrate paper system of Curry and Powell. In order to overcome the slowness (which can be a serious disadvantage with this paper system in diagnosis of acute poisoning) without recourse to a new thin-layer chromatographic system and consequent sacrifice of results, a system has been developed that gives RF values which, for practical purposes, are substantially the same as those in the paper system, for the limited range of drugs examined and for their extracts from horse urine. It is unlikely that the correlation is due to chance, and it is considered, therefore, that the more rapid thin-layer chromatographic system can be substituted for the paper system.

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