Supercritical fluid extraction of active components in a drug formulation
- 1 May 1992
- journal article
- research article
- Published by American Chemical Society (ACS) in Analytical Chemistry
- Vol. 64 (9) , 981-984
- https://doi.org/10.1021/ac00033a004
Abstract
Sulfamethoxazole and trimethoprim have been extracted from a drug formulation, Septra Infusion, with pure supercritical carbon dioxide. Both direct extraction of the aqueous-based matrix and indirect extraction of the formulation immobilized onto Celite were studied. Exhaustive analytical extraction was achieved when active components were less than 1.0 mg. A number of co-extractants were found, but each was blind to the HPLC/UV assay.Keywords
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