Effects of amidines on oxidases of Escherichia coli and of animal tissues

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Abstract
The respiration of washed cells of E. coli in presence of various substrates was strongly inhibited by propamidine, hexamidine, dibromopropamidine and mono-iodohexamidine in concns. of the order of 1.25-12.5 x 10-5 [image]. There was no simple relationship between the bacteriostatic potencies of the amidines and their effects on respiration. Propamidine had no effect on several tissue oxidation systems, but inhibited the choline oxidase of liver.

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