Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents.
- 30 April 1996
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 93 (9) , 4159-4164
- https://doi.org/10.1073/pnas.93.9.4159
Abstract
Many studies of caloric restriction (CR) in rodents and lower animals indicate that this nutritional manipulation retards aging processes, as evidenced by increased longevity, reduced pathology, and maintenance of physiological function in a more youthful state. The anti-aging effects of CR are believed to relate, at least in part, to changes in energy metabolism. We are attempting to determine whether similar effects occur in response to CR in nonhuman primates. Core (rectal) body temperature decreased progressively with age from 2 to 30 years in rhesus monkeys fed ad lib (controls) and is reduced by approximately 0.5 degrees C in age-matched monkeys subjected to 6 years of a 30% reduction in caloric intake. A short-term (1 month) 30% restriction of 2.5-year-old monkeys lowered subcutaneous body temperature by 1.0 degrees C. Indirect calorimetry showed that 24-hr energy expenditure was reduced by approximately 24% during short-term CR. The temporal association between reduced body temperature and energy expenditure suggests that reductions in body temperature relate to the induction of an energy conservation mechanism during CR. These reductions in body temperature and energy expenditure are consistent with findings in rodent studies in which aging rate was retarded by CR, now strengthening the possibility that CR may exert beneficial effects in primates analogous to those observed in rodents.Keywords
This publication has 27 references indexed in Scilit:
- Dietary Restriction of Adult Male Rhesus Monkeys: Design, Methodology, and Preliminary Findings From the First Year of StudyJournal of Gerontology, 1993
- Dietary Restriction Alters Characteristics of Glucose Fuel UseJournal of Gerontology, 1992
- Dietary Restriction and Aging: The Initiation of a Primate StudyJournal of Gerontology, 1990
- Effect of chronic caloric restriction on physiological variables related to energy metabolism in the male Fischer 344 ratMechanisms of Ageing and Development, 1989
- The EFF the effect of dietary restriction of MYC protooncogene expression in mice: A preliminary studyMechanisms of Ageing and Development, 1989
- Effect of chronic undernutrition on susceptibility to cold stress in young adult and aged ratsMechanisms of Ageing and Development, 1988
- Effect of intermittent feeding on thermoregulatory abilities of young and aged C57BL/6J miceArchives of Gerontology and Geriatrics, 1985
- Hibernation and Longevity in the Turkish Hamster Mesocricetus brandtiScience, 1981
- Heat-induced deamination of cytosine residues in deoxyribonucleic acidBiochemistry, 1974
- Rate of depurination of native deoxyribonucleic acidBiochemistry, 1972