Morphological Classification of Liver Cirrhosis Based upon Measurement of Per Cent of Interstitial Tissue in Liver Biopsy Specimens

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Abstract
Per cent of interstitial tissue was measured in liver biopsy specimens of 62 patients with liver cirrhosis. The frequency curve of the per cent of interstitial tissue showed 2 peaks in 10-19 per cent and in 40-49 per cent, a dell being observed at 30%. Therefore, liver cirrhosis could be classified into 2 groups, i. e., the group with less than 30 per cent of interstitial tissue and the group with 30% or more of interstitial tissue. Edema, liver enlargement, abnormalities in thymol flocculation test, in cephalin cholesterol flocculation test, and in serum [gamma] -globulin concentration, and deformity of the hepatic veins in hepatic venograms were ail significantly more frequently observed in the group with 30% or more of interstitial tissue than in the group less than 30% of interstitial tissue. There was significant correlation between the per cent of interstitial tissue and the per cent of intrahepatic shunt.