EFFECT OF ROUTE OF ADMINISTRATION ON THE DISPOSITION OF INULIN ENCAPSULATED IN MULTILAMELLAR VESICLES OF DEFINED PARTICLE-SIZE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 27  (2) , 293-304
Abstract
The effect of multilamellar vesicle (MLV) size and route of administration on the tissue distribution [in mice] of inulin encapsulated in phosphatidyl choline, cholesterol, phosphatidyl serine and .alpha.-tocopherol liposomes was investigated. Large MLV (2.7-4.9 .mu.m) administered i.v. delivered a large fraction of the dose to the liver, lungs and spleen. When large MLV were given i.m. (left thigh muscle), a smaller fraction of the absorbed dose was distributed to these organs. Small MLV (0.3-0.8 .mu.m) administered by either route resulted in a smaller fraction of the dose distributing to the liver, lungs and spleen compared to large MLV. Release from the injection site was size-dependent with a larger fraction of the i.m. dose remaining at 24 h for the large MLV.