Eine für die Berechnung der intestinalen Vitamin B12-Resorption beim Menschen sowohl im physiologischen, Intrinsic Factor-abhängigen als auch im unphysiologisch hohen, diffusionsbedingten Dosisbereich allgemein gültige Formel
Open Access
- 1 November 1965
- journal article
- research article
- Published by Walter de Gruyter GmbH in Zeitschrift für Naturforschung B
- Vol. 20 (11) , 1067-1069
- https://doi.org/10.1515/znb-1965-1108
Abstract
The intestinal absorption of pure 60Co-cyanocobalamin was measured in human beings in the dose range between 0.10 and 100,000 µg with the radio-vitamin B12-absorption-whole body retentiontest. The 60Co-vitamin B12-whole body-retention was measured within the 200 cm long 4 п detector geometry of a large volume radioactivity detector with liquid organic scintillator. The estimated intestinal 60Co-vitamin B12 absorption in man can be described for the whole dose range (0.10 —100,000 µg) by two equations which contain expressions for the intrinsic factordependent vitamin B12 absorption and the diffusion absorption of vitamin B12 [see equations (1) and (2) ]. It is evident from these equations that intrinsic factor-dependent vitamin B12-absorption is limited to 1.5 µg B12/dose whereas the diffusion absorption of vitamin B12 approaches but never exceeds 0.90% of the oral dose. The diffusion absorption rate can be used together with the vitamin B12-whole body turnover rate (~ 2.6 µg/day) as an experimental basis for an efficient oral vitamin B12-therapy with high doses.This publication has 0 references indexed in Scilit: