The Importance of Ventilation in Exercise-Induced Asthma

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Abstract
The degree of post-treadmill-running decrease in pulmonary function (exercise induced asthma) in 11 adult [human] asthmatics was compared to the decrease in pulmonary function followed by resting isocapnic hyperventilation. Ventilation during hyperventilation was kept identical to ventilation during treadmill running by continuous recording of respiratory frequency, minute ventilation, tidal volume and accumulated ventilation. The temperature of the inspired air was identical in the 2 situations and the relative humidity was 40% during treadmill running and 15% during hyperventilation. The average accumulated ventilation during treadmill running and hyperventilation was 411 1/6 min in both events. The decrease in peak expiratory flow after treadmill running was 25% and after isocapnic hyperventilation 24%. Ventilation is of more importance than the work load for the decrease in pulmonary function after exercise.