THE EFFECT OF CHLORDIAZEPOXIDE AND PETHIDINE, ALONE AND IN COMBINATION, ON THE RESPIRATORY RESPONSE TO CARBON DIOXIDE
Open Access
- 1 June 1967
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 39 (6) , 459-463
- https://doi.org/10.1093/bja/39.6.459
Abstract
The respiratory effects following the intravenous administration of chlordiazepoxide (1 mg/kg) and pethidine (0.5 mg/kg), both alone and as a mixture, were studied by means of carbon dioxide stimulus-response curves. Eight healthy adult volunteers demonstrated no statistically significant respiratory depression after receiving chlordiazepoxide. Pethidine alone caused depression for 2 hours, and in combination with chlordiazepoxide the duration was prolonged to 4 hours (the duration of the study period).Keywords
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