Tetracycline Fluorescence and Enzyme Histochemistry on Early Radiation Damage in Mouse Kidney

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Abstract
There was an increase in the tetracycline fluorescence of tubule cells as early as 2-4 hr. after irradiation. Aminopeptidase and cytochrome oxidase activity decreased at 4 hr., and acid phosphatase at 8 hr. At 24 hr., there were large cortical areas, showing little or no enzyme activity. The changes in enzyme activity and in tetracycline fluorescence revealed early signs of imminent necrosis, long before there was histological evidence of cell damage.