Sialadenitis and Systemic Reaction Associated with Phenylbutazone

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Abstract
Sialadenitis is an uncommon side effect of phenylbutazone, and 7 patients with this reaction were studied over a 7-yr period. In addition to salivary gland swellings, all patients had evidence of a systemic disturbance that included fever in all cases and, in varying combinations, pericarditis, pleurisy, rash, conjunctivitis and disturbed hepatic function. Resolution of these features occurred following cessation of phenylbutazone, but this took several weeks in some cases. Pericarditis was the most severe manifestation, and in 1 patient this required corticosteroid therapy.