Relation of Concentrations of Bacteria and Bacterial Antigen in Cerebrospinal Fluid to Prognosis in Patients with Bacterial Meningitis

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Abstract
Previous investigators have shown that patients with meningitis who have relatively large amounts of bacterial antigen in cerebrospinal fluid are more likely to have neurologic sequelae,1 subdural effusions,2 prolonged fever3 , 4 or greater morbidity and mortality5 than patients with lower amounts.Although these workers considered the levels of bacterial antigen related to the concentrations of bacteria, no direct evidence was available since concentrations of bacteria were not measured. Recently, I reported preliminary data showing that antigen levels in cerebrospinal fluid of 15 patients were significantly (P6 From these data, I hypothesized that concentrations of bacteria were . . .