Some New Bifunctional Reagents for the Conjugation of a Protein with an Amino Compound in Water

1 January 1975

journal article
Published by Walter de Gruyter GmbH in Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie

Vol. 356 (2) , 1625-1630
https://doi.org/10.1515/bchm2.1975.356.2.1625

Abstract

Five symmetrical bifunctional reagents (I-V) have been synthesized and tested for their usefulness for the conjugation of albumin with tryptophan, in aqueous solution. With I and II about 17, with IV and V about 8 tryptophan residues could be introduced in the native protein. The difference is discussed. Reagent III has a very low solubility in water but may be useful if organic solvents are permissible.

Keywords

PROTEIN
BIFUNCTIONAL REAGENTS
CONJUGATION
PERMISSIBLE
AMINO
NATIVE
III

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