CONTROL OF VIRAL MESSENGER RNA AFTER LAMBDA PHAGE INFECTION AND INDUCTION

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Abstract
[lambda] mRNA levels are very low in cells lysogenic for [lambda] , but increase to very high levels following induction. Infection of sensitive cells with [lambda] + and [lambda] v produces an immediate marked increase in [lambda] mRNA levels. In the case of [lambda] v infection there is a transition to still higher levels late in infection; the early increase after [lambda] v infection is not blocked by chloramphenicol, but the late burst to a high [lambda] mRNA level is chloramphenicol-senstive. The immunity of cells lysogenic for [lambda] specifically prevents the increases in [lambda] mRNA levels following [lambda] + infection. [lambda] mRNA levels in [lambda] v infection of lysogenic cells are initially repressed, but [lambda] v is capable of overcoming this repression unless protein synthesis is blocked.