IgG Anti-IgA1 and Anti-IgA2 Antibodies: Their Measurement by an Enzyme-Linked Immunosorbent Assay and Their Relationship to Disease
- 1 January 1986
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 80 (4) , 337-341
- https://doi.org/10.1159/000234078
Abstract
IgG anti-IgA antibodies were measured by an enzyme-linked immunosorbent assay using one IgA1 and one IgA2 (ml) myeloma and a pooled IgA protein preparation as antigens. Class-specific anti-IgA antibodies occurred in 0.8% of non-IgA-deficient sera and 24.3% of IgA-deficient sera. Antibodies reacting with IgA1 only occurred in 2.6% of non-IgA-deficient sera and 6.7% of IgA-deficient sera. Antibodies reacting with IgA2 only occurred in 0.6% of non-IgA-deficient sera and 2.7% of IgA-deficient sera. The prevalence of anti-IgA in IgA deficients with inflammatory disease was higher (81.8%) than in IgA deficients without disease (24.1 %) and was accounted for by class-specific antibodies.Keywords
This publication has 0 references indexed in Scilit: