AGE RESPONSE TO X-RADIATION OF MURINE LYMPHOMA CELLS SYNCHRONIZED in vivo
- 1 July 1969
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 63 (3) , 686-691
- https://doi.org/10.1073/pnas.63.3.686
Abstract
Cells of a transplantable murine lymphoma line were partially synchronized in vivo by administration of a single dose of 0.5 mg of hydroxyurea per lymphoma-bearing mouse. At various times after administration of hydroxyurea, the femurs of the lymphomatous mice were X-irradiated, and the number of lymphoma colony-forming units per femur were then assayed by the spleencolony technique. A well-defined age response to irradiation of the lymphoma cells in vivo, similar to that of HeLa cells in vitro, was observed.Keywords
This publication has 17 references indexed in Scilit:
- Interphase action of vinblastine and vincristine: Differences in their lethal action through the mitotic cycle of cultured mammalian cellsJournal of Cellular Physiology, 1968
- Sub-lethal and Lethal Radiation DamageNature, 1967
- The Dose-survival Relationship for Irradiation of Epithelial Cells of Mouse SkinThe British Journal of Radiology, 1967
- ACTION OF HYDROXYUREA ON NUCLEIC ACID METABOLISM AND VIABILITY OF HELA CELLS1967
- Hydroxyurea: Differential Lethal Effects on Cultured Mammalian Cells during the Cell CycleScience, 1965
- A Quantitative Assay for the Number of Murine Lymphoma Cells capable of Proliferation in vivoNature, 1963
- Growth and nucleic acid synthesis in synchronously dividing populations of HeLa cellsExperimental Cell Research, 1963
- A METHOD OF ANALYZING FOR HYDROXYUREA IN BIOLOGICAL FLUIDS1963
- Variations in Several Responses of HeLa Cells to X-Irradiation during the Division CycleBiophysical Journal, 1963
- A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow CellsRadiation Research, 1961