Peptide modulators of protein–protein interactions in intracellular signaling
- 1 October 1998
- journal article
- review article
- Published by Springer Nature in Nature Biotechnology
- Vol. 16 (10) , 919-924
- https://doi.org/10.1038/nbt1098-919
Abstract
Signal transduction cascades involve multiple enzymes and are orchestrated by selective protein-protein interactions that are essential for the progression of intracellular signaling events. Modulators of these protein-protein interactions have been used to dissect the role of individual components of each signaling cascade. We describe several methods that have been developed for the identification of peptides that inhibit the interaction between signaling proteins and hence selectively modulate their functions. Such peptide modulators provide important tools for basic research and have great potential as leads for the development of new classes of therapeutic drugs.Keywords
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