POTENTIATION OF SUBSTANCE P BY LYSERGIC ACID DIETHYLAMIDE IN VIVO
Open Access
- 1 June 1961
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 16 (3) , 253-256
- https://doi.org/10.1111/j.1476-5381.1961.tb01084.x
Abstract
In doses of 10 μg/kg or more, lysergic acid diethylamide enhanced the fourth potential (DR IV) of the dorsal root potential complex in the cat. Smaller doses of lysergic acid diethylamide did not in themselves alter the DR IV, but revealed an enhancement of the potential by substance P, which by itself had no effect. 2-Bromolysergic acid diethylamide had no action on the dorsal root potentials, but prevented the actions of lysergic acid diethylamide.Keywords
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