Allergic Interstitial Nephritis Causing Reversible Renal Failure in Four Patients with Idiopathic Nephrotic Syndrome

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Abstract
In four patients with pre-existing proliferative glomerulonephritis and the nephrotic syndrome allergic interstitial nephritis developed that resulted in moderate to severe, but reversible, renal failure. In three of these patients clinical evidence for a hypersensitivity reaction was present. In all cases renal biopsy revealed a diffuse interstitial infiltrate containing many eosinophils. Cessation of furosemide or thiazides, coupled with the institution of prednisone therapy, was followed by dramatic improvement of renal function. None of the known causes of interstitial nephritis were detected. Although a definite etiologic relation has not been established, the diuretic agents employed may have been responsible for the interstitial nephritis in these cases.

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