Autoradiographic investigation of proliferative responses in rat incisor pulp after vincristine administration
- 1 April 1980
- journal article
- research article
- Published by Wiley in European Journal of Oral Sciences
- Vol. 88 (2) , 96-103
- https://doi.org/10.1111/j.1600-0722.1980.tb01200.x
Abstract
VCR [Vincristine] (0.7 mg/kg) was given to 9 rats in 3 experimental groups, and 23 h later, the animals were injected with 3H-thymidine. The animals were then sacrificed 24, 48 and 72 h after the VCR injection, and by comparison with 9 control animals similarly injected with NaCl solution and nucleotide, VCR causes a delayed migration of pulp cells from the proliferative pool and a small but distinct inhibition of the incisal growth of the incisors. The growth inhibition corresponded to the normal growth over a 24 h period in non-VCR-injected animals.Keywords
This publication has 3 references indexed in Scilit:
- Cellular renewal in the enamel organ and the odontoblast layer of the rat incisor as followed by radioautography using 3H‐thymidineThe Anatomical Record, 1975
- The proliferation of pulp cells in rat incisorsArchives of Oral Biology, 1967